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Short Course

Human exposure to arsenic through food chain: Risk reduction and mitigation

Venue: The Friendship Hotel of Beijing
Date and Time: June 30-July 1 (Two days)
Course organizers
Mohammad Alauddin, Professor, Department of Chemistry, Wagner College, Staten Island, New York, USA
Parvez I Haris, Professor, Faculty of Health & Life Sciences, De Montfort University, Leicester, United Kingdom
Jack Ng, Professor, Queensland Alliance for Environmental Health Sciences, Faculty of Health and Behavioral Science, The University of Queensland, Brisbane, QLD, Australia
Debapriya Mondal, PhD, School of Environment & Life Sciences, University of Salford, Salford, United Kingdom
Ashok K Ghosh, Professor, Mahavir Cancer Research Institute, Patna, India
Celia Jones, PhD. Kemakta AB, Stockholm, Sweden
Prosun Bhattacharya, Professor, Department of Sustainable Development, Environmental Science and Engineering, KTH Royal Institute of Technology, Stockholm, Sweden

Accumulation of arsenic in different foods, especially rice and exposure to populations is not just limited to those residing in areas with geogenic exposure from drinking water. Currently, assessment of human dietary exposure to arsenic is of great global significance.  Though, the joint FAO-WHO Codex Alimentarius Commission in July 2014 established a maximum level of 0.2 mg/kg for inorganic arsenic in polished rice but similar assessment for other food products is limited. Also, limited are studies on arsenic bioavailability from different foods in spite of the fact that bioavailability of arsenic and its speciation play a vital role in human health risk assessment.

Course contents
This course will be divided into three modules:
Module 1 (M-I): General background
M-I.1: Arsenic: Translocation of arsenic from irrigation water to soil to plants- the Water-soil-plant-food nexus.
M-I.2: Determination of arsenic in foods (Sample collection to digestion & ICP-MS analysis)

Module 2 (M-II): Estimation of arsenic exposure and risk assessment
M-II.1: Methods for estimating arsenic intake from foods (Total Diet Study, Food Frequency Questionnaire etc)
M-II.2: Determination of human exposure to arsenic from foods (Human biomonitoring: urine analysis etc)
M-II.3: Risk assessment of exposure to arsenic from foods (Cancer risk estimation etc.)

Module 3 (M-III): Strategies for reduction of arsenic exposure and management of risks
M-III.1: Strategies for reducing arsenic exposure through foods (Cooking methods, low arsenic rice etc.)
M-III.2: Nutritional supplements to ameliorate impact of arsenic poisoning
M-III.3: Developing a protocol for management of risks for arsenic exposure from food– policy perspectives on risk mitigation.

Learning outcomes
After the successful completion of the course, the participants will be able to:
develop  systematic approach for assessment of human dietary exposure to arsenic
understand the importance of differentiating between estimates of intake of contaminated food versus biological measures of internal dose of arsenic
identify challenges in dietary exposure assessment under various cultural practices and food habits
understand arsenic exposure in populations around the world emphasising the importance of strategies to prevent this exposure and impact on human health
develop effective strategies in collaboration with affected community to prevent or reduce dietary exposure to arsenic
identify food regimen in the affected communities that can provide essential nutrients and antioxidants to counter toxicity of arsenic
develop a protocol for management of risks of arsenic exposure through food and develop science based policy perspectives on risk reduction.

About the Course Organizers

Mohammad Alauddin, Ph.D. is a Professor, Department of Chemistry, Wagner College since 1993, held Megerle Endowed Chair in Wagner College. He has worked as United Nations Development Program (UNDP) consultant in the Bangladesh Atomic Energy Commission (1993) and involved in assessment of arsenic in groundwater in Bangladesh and technical assistance in monitoring arsenic in groundwater. Served as Fulbright Scholar and Specialist (2004, 2015), USAID consultant (2004) in Bangladesh. Research interests and current projects include investigating arsenic, in drinking water and food, exposure to toxic elements in human, and developing techniques for speciation of arsenic metabolites in biological tissues to assess health risk. Co-PI in two clinical trials (NIH, American Cancer Society USA funded project) involving micronutrient supplementation to counter arsenic toxicity in Bangladesh. He has collaborative research with institutions in the USA, Canada, Bangladesh, India, Kenya and Australia. He has advocated and convened topical sessions on arsenic in the Geological Society of America (GSA) and the American Geophysical Union (AGU) meetings. Guest editor on several occasions for the Journal of Environmental Science and Health, Taylor & Francis Group, London, UK.

Parvez I Haris, PhD, is a Professor and Head of the Biomedical & Environmental Health Group at De Montfort University, Leicester, UK. His research interest includes understanding the relationship between diet, nutrition and health with particular focus on arsenic.

Debapriya Mondal, PhD (Senior Lecturer at University of Salford) is an environmental epidemiologist with significant experience and understanding of dietary correlates of arsenic exposure and arsenic induced health outcomes.

Ashok Kumar Ghosh, PhD is working as Professor and HoD, Research at Mahavir Cancer Institute and Research Centre, Patna, India .Currently he is working on a multinational (Indo-Dutch-BD) research project DELTAP to study arsenic mobilization in Gangetic floodplains of Bihar supported by NWO-Wotro – The funding agency of The Netherlands Government. Dr.Ghosh is also working on DST-UKIERI supported project Nutri-SAM to study amelioration of arsenic poisoning through nutrition, jointly with University of Salford ,UK.

Celia Jones, PhD works as a consultant at Kemakta Konsult AB, Stockholm, Sweden. She works mainly with assessments of the risks of environmental contaminants to health and the environment, and has been involved in the development of guidelines for contaminated soils for the Swedish Environmental Protection Agency. She has assessed the risks from arsenic in contaminated soils at a number of sites in Sweden.

Jack Ng, PhD, Professor, Professor Jack Ng is a certified toxicologist (DABT - Diplomate of the American Board of Toxicology). Jack joined the University of Queensland in 1977 and is a Professor in Environmental Toxicology at the Queensland Alliance for Environmental Health Sciences (QAEHS), which incorporates the former National Research Centre for Environmental Toxicology (Entox), Faculty of Health and Behavioural Sciences. Jack is the Research Theme Leader for Environmental Health Risk Assessment. Jack is also a Program Leader for the “Minimising Uncertainty in Risk Assessment” in the Australian Government funded Cooperative Research Centre for Contamination Assessment and Remediation of the Environment (CRC CARE). His major research themes include metal speciation of contaminants in the environmental and biological media, bioavailability in relationship to toxicity using various animal and cell models, carcinogenicity and mechanistic studies of metal/loid toxicity in both humans and animals. Jack and his team were the first to have demonstrated that MMAIII, a methylated trivalent arsenic metabolite, is a carcinogen in an in-vivo mouse model. This is a landmark study in arsenic research in addition to his initial proof of the carcinogenic effect of inorganic arsenic in-vivo. His other research interests include metal and organic chemical exposure assessment and interaction toxicology in both in vivo and in vitro systems, natural toxins relevant to human health and toxicity of particles.  At international level, Jack’s expertise has been recognised by World Health Organisation (WHO), International Agency for Research on Cancer (IARC), and WHO/FAO Joint Expert Committee on Food Additives (JECFA) as demonstrated by his contribution to a number of monographs and technical reports produced by these agencies. Jack has over 450 publications of which about half are peer-reviewed articles.

Prosun Bhattacharya, PhD is a Professor of Groundwater Chemistry and Coordinator of the KTH-International Groundwater Arsenic Research Group, at the Department of Sustainable Development, Environmental Science and Engineering at KTH Royal Institute of Technology, Stockholm, Sweden. Currently he is also affiliated to the School of Civil Engineering & Surveying, International Centre for Applied Climate Science at the University of Southern Queensland, Australia as an Adjunct Professor. His research focusses on geogenic contamination in groundwater resources in different parts of the world, especially focusing on contaminants – arsenic and fluoride. He has collaborative research with universities and research organizations in India, Bangladesh, China, Australia, Argentina, Ghana, Costa Rica, Bolivia, Tanzania, Turkey and USA. He has coordinated the prestigious Swedish International Development Cooperation Agency supported action research and implementation project “Sustainable Arsenic Mitigation-SASMIT” Community driven initiatives to target arsenic safe groundwater as sustainable mitigation strategy in Bangladesh (2007-2016).

Course registration and price:
As2018 Congress Student delegates: USD 100/RMB 600
All other students: USD 100/RMB 600
Other Professionals: USD 150/RMB 900
The course fee includes the course compendium with the teaching materials, lunch and the refreshments.