Published in 2017-08-03 10:50:18
Take title：Pathways of organoarsenic biosynthesis and detoxification
Barry P. Rosen is currently Distinguished Professor at the Herbert Wertheim College of Medicine, Florida International University in Miami, Florida since 2009. He was Associate Dean for Basic Research and Graduate Programs from 2009-2016. For 22 years he was Chair and Distinguished Professor of Biochemistry and Molecular Biology at Wayne State University School of Medicine in Detroit, Michigan. He received his B.S. from Trinity College, Hartford, Connecticut in 1965 and his M.S. (1968) and Ph.D. (1969) from the University of Connecticut and was an NIH postdoctoral fellow at Cornell University (1969-1971). He was on the faculty at the University of Maryland School of Medicine in Baltimore, Maryland for 15 years.
For nearly four decades his laboratory has investigated the mechanisms of transport and detoxification of transition metals, heavy metals and metalloids in bacteria, yeast, protozoans, mammals and plants. He identified the pathways of arsenic uptake, efflux, biotransformation and regulation in organisms from E. coli to humans. He identified most of the known arsenic detoxification genes and characterized their gene products at the biochemical and structural level. He solved the crystal structure of the ArsA As(III)- translocating ATPase, the ArsR repressor orthologue CadC, the ArsC and LmAcr2 arsenate reductases, the ArsH NADPH-FMN oxidoreductase, the ArsD As(III) metallochaperone, the ArsM As(III)-SAM methyltransferases from Cyanidioschyzon merolae and Chlamydomonas reinhardtii and most recently the ArsI C-As lyase. He identified and named the ArsR family of metalloregulatory proteins. He made the seminal discovery that aquaglyceroporin channels, from E. coli GlpF to human AQP9, are the transporters that nearly every cell uses to take up As(III). He is currently elucidating the enzymes and transporters of the arsenic biomethylation and organoarsenical redox cycles. He has published more than 320 papers, reviews and books and is the holder of two R01 grants from NIGMS and NIEHS. His recent publication was used for the cover of Chemical Research in Toxiciology.
He is recipient of numerous awards, including a MERIT Award from the National Institute of Health, Basil O'Connor Award from the March of Dimes, Maryland Distinguished Young Scientist Award, Josiah Macy, Jr. Faculty Scholar Award, Gershenson Distinguished Faculty Fellow Award (WSU), Outstanding Graduate Mentor Award (WSU) and Lawrence Weiner Medical Alumni Award (WSU) and is an elected fellow of both the American Association for the Advancement of Science (AAAS) and the American Society for Microbiology (ASM). He has been on many national and international panels at NIH, NSF, and American Heart Association, and on multiple editorial boards. He has served as both President of the Wayne State University Academy of Scholars and President of the Association of Medical and Graduate Departments of Biochemistry. He was recently a reviewer of the FDA policy on arsenic in rice.